上海
膦酸二烷基酯鋰鹽親核進攻吡啶-N-氧化物得到二位吡啶膦酸二烷基酯的反應。類似反應。
反應操作：
Diethyl pyridine-2-phosphonate (5). BuLi (23% in hexane) (12.6 mL, 0.03 mol) was added dropwise to diethyl phosphonate (5.0 g, 0.036 mol) at-20 to-30 oC over 2 h. To the resulting 3 was added 2 (from Pyr N-oxide 2.83 g, 0.03 mol and dimethyl sulfate 3.78 g, 0.03 mol) in diethyl phosphonate (8 mL) over 1 h at -15 C. The mixture was stirred at r.t. overnight and water (20 mL) was added. After extraction with CHCl3 (3 15 mL), the organic layer was extracted with 4N HCl, basified and reextracted to afford 5.2 g (67%) of 5.
【Gordon M, J Org Chem., 1966, 31, 333】
相關文獻
1 Michaelis A Chem Ber 1897 30 1003
2 Michaelis A Chem Ber 1898 31 1048
3 Nylen T Chem Ber 1924 57 1023
4 Gordon M J Org Chem 1966 31 333
5 Redmore D J Org Chem 1970 35 4114
6 Kem KM J Org Chem 1981 46 5188
7 Stevens CV Chem Rev 2009 109 2672
編譯自：Organic Syntheses Based On Name Reactions, 3RdEd, A. Hassner, Page 318.
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